Table 3.

Association between immune cell phenotypes and overall survival.

		TUMOR						STROMA
		Univariate			Multivariable*			Univariate
	n	HR (95% CI)	p-value	n	HR (95% CI)	p-value	n	HR (95% CI)	p-value
CD8+ FOXP3+	105	7.80 (2.48–24.47)	4.36 × 10 −4	104	0.84 (0.17–4.15)	0.832	97	n/a	0.997
CD8− FOXP3+	105	2.35 (1.15–4.78)	0.019	104	1.60 (0.58–4.36)	0.362	97	1.04 (0.61–1.77)	0.882
CD68+ PDL1−	114	1.89 (1.08–3.32)	0.026	111	1.43 (0.78–2.61)	0.248	109	1.82 (0.95–3.49)	0.071
Plasma cell	102	0.53 (0.30–0.94)	0.03	100	0.53 (0.27–1.06)	0.07	102	1.47 (0.86–2.50)	0.156
CD4+ T cells	97	1.76 (0.98–3.17)	0.057				97	1.2 (0.76–1.89)	0.431
CD68+ PDL1+	114	1.84 (0.95–3.58)	0.070				109	1.12 (0.61–2.03)	0.72
PD1+	114	1.27 (0.72–2.22)	0.406				109	0.99 (0.67–1.48)	0.971
PDL1+	114	1.13 (0.69–1.87)	0.616				109	1.12 (0.72–1.75)	0.626
CD20+ B cells	102	0.91 (0.53–1.56)	0.736				102	0.82 (0.51–1.31)	0.402
CD8+ T cells	105	1.01 (0.64–1.59)	0.957				97	1.25 (0.87–1.80)	0.23

^*Adjusted for age, stage, stratified by study site.