Table 1. Diagnostic performance of both the computer-aided diagnosis system and endoscopists for differentiating neoplastic from non-neoplastic diminutive lesions. ¹ .

	Overall		Proximal to rectosigmoid		Rectosigmoid
	CADx	Endoscopists	CADx	Endoscopists	CADx	Endoscopists
All predictions, n	423	423	301	301	122	122
All predictions, % (95 %CI)
Accuracy	79.4 (75.2–83.2)	83.0 (79.1–86.4)	81.4 (76.5–85.6)	82.4 (77.6–86.5)	74.6 (65.9–82.0)	84.4 (76.8–90.4)
Sensitivity	89.4 (86.2–92.7)	92.4 (89.6–95.2)	88.7 (84.9–92.3)	92.6 (89.4–95.8)	91.4 (85.4–97.5)	91.7 (85.8–97.6)
Specificity	37.8 (27.3–48.3)	43.9 (33.2–54.6)	38.6 (24.3–53.0)	22.7 (10.3–35.1)	38.8 (22.9–54.8)	68.4 (53.6–83.2)
PPV	85.7 (82.0–89.3)	87.3 (83.8–90.7)	89.4 (85.6–93.2)	87.5 (83.6–91.4)	77.3 (69.0–85.7)	86.5 (79.4–93.6)
NPV	46.3 (34.3–58.2)	58.1 (45.8–70.4)	34.5 (23.0–50.9)	34.5 (17.2–51.8)	66.7 (46.5–86.8)	78.8 (64.8–92.7)
Only high-confidence predictions, n	422	367	301	263	121	101
Only high-confidence predictions, % (95 %CI)
Accuracy	79.6 (75.5–83.3)	85.8 (81.8–89.2)	81.4 (76.5–85.6)	85.6 (80.7–89.6)	75.2 (66.5–82.6)	86.9 (79.0–93.7)
Sensitivity	89.4 (86.2–92.7)	94.7 (92.1–97.2)	88.7 (84.9–92.6)	95.6 (92.9–98.3)	91.7 (85.8–97.6)	91.9 (85.7–98.1)
Specificity	38.3 (27.7–48.9)	47.1 (35.2–58.9)	38.6 (24.3–53.0)	26.3 (12.3–40.3)	37.8 (22.2–53.5)	73.3 (57.5–89.2)
PPV	85.9 (82.3–89.5)	88.7 (85.2–92.2)	89.4 (85.6–93.2)	88.5 (84.4–92.5)	77.0 (68.7–85.3)	89.5 (82.6–96.4)
NPV	46.3 (34.3–58.2)	66.7 (53.3–80.0)	37.0 (23.0–50.9)	50.0 (28.1–71.9)	66.7 (46.5–86.8)	78.6 (63.4–93.8)

CADx, computer-aided diagnosis; PPV, positive predictive value; NPV, negative predictive value.

¹For the calculation of the diagnostic accuracies (neoplastic vs. non-neoplastic), adenomas and sessile serrated lesions (SSL) were considered neoplastic polyps, while hyperplastic polyps were considered non-neoplastic. Note that when an SSL was assessed as an adenoma or vice versa, this was also considered