TABLE 2.

A summary of the structural characteristics for some artificial NVPNs. The indicated code corresponds to the respective PDB ID.

Protein nanocages	Structural characteristics				References
	Number of monomers	Molecular weight	Geometry	Dimensions a
16-nm protein nanocages designed (3VDX, Figure 2A)	12	600 kDa	Tetrahedral	OD: 16 nm; ID: n.a	Lai et al. (2012a)
His6-HuHF and His6-SF nanocages (7CPC, Figure 2B)	24	514 kDa	Octahedral	OD: 12 nm; ID: n.a	Gu et al. (2020)
trp RNA-binding attenuation protein (TRAP) nanocages (6RVW, Figure 2C)	24	2.2 MDa	Octahedral	OD: 22 nm; ID: 16 nm	Heddle et al. (2006), Heddle et al. (2007), Malay et al. (2019), Naskalska et al. (2021), Majsterkiewicz et al. (2022), Stupka et al. (2022)
I3-01 nanocages (8ED3, Figure 2D)	60	1.3 MDa	Icosahedral	OD: 26 nm; ID: n.a	Hsia et al. (2016), Votteler et al. (2016), Bruun et al. (2018), McCarthy and Gonen (2022), SIB Swiss Institute of Bioinformatics (2023)
Prototype oxygen-impermeable protein nanocages (OIPNC) (7WKC, Figure 2E)	n.a	n.a	Icosahedral	OD: 14 nm; ID: n.a	Gao et al. (2022)
TIP60 nanocages (7EQ9; Figure 2F)	60	1.1 MDa	Icosahedral	OD: 21.7–24.7 nm; ID: 15 nm	Kawakami et al. (2018), Obata et al. (2021), Ohara et al. (2023)

^a OD, outer diameter; ID, inner diameter; n.a, not available.