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. 2023 Jul 11;42(31):2363–2373. doi: 10.1038/s41388-023-02773-9

Fig. 3. Positions of BRG1 ATPase domain mutations reported in brain cancer and the targets of BRG1 inhibitors.

Fig. 3

BRG1 is a 1647 amino acid protein encoded by the SMARCA4 gene, with the ATPase domain spanning amino acids 750–1250. DEAD-like helicases superfamily domain (DEXDc) and helicase superfamily c-terminal domain (HelicaseC) provide the catalytic activity of the ATPase domain. BRM014 inhibits BRG1 via targeting the ATPase domain, whilst the inhibitor PFI-3 targets the bromodomain. Created with BioRender.com.