Table 2.
General characteristics of study population according to MC4R rs17782313tertiles of MC4R in obese and overweight women (n = 279).
| Variables† | MC4R | ||||
|---|---|---|---|---|---|
| Mean ± SD | P-value | P-value* | |||
| TT = 114 | TC = 73 | CC = 92 | |||
| Age (years) | 36.78 ± 8.09 | 36.64 ± 9.45 | 35.98 ± 8.12 | 0.78 | 0.37 |
| Anthropometric measurements | |||||
| Weight (kg) | 80.49 ± 11.43 | 79.34 ± 10.06 | 79.89 ± 10.90 | 0.77 | 0.21¥ |
| Height (cm) | 161.83 ± 5.95a | 161.14 ± 5.55b,a | 160.83 ± 5.88c | 0.44 | < 0.001¥ |
| WC (cm) | 98.90 ± 9.91 | 97.93 ± 8.60 | 98.19 ± 9.15 | 0.76 | 0.25¥ |
| WHR | 0.93 ± 0.05 | 0.93 ± 0.04 | 0.92 ± 0.04 | 0.25 | 0.08¥ |
| BMI (kg/m2) | 30.77 ± 3.79 | 30.53 ± 3.60 | 30.83 ± 3.76 | 0.87 | 0.87¥ |
| VFL (cm2) | 18.33 ± 22.15 | 15.31 ± 3.01 | 15.48 ± 3.24 | 0.25 | 0.22¥ |
| FFMI | 17.95 ± 1.44 | 17.86 ± 1.45 | 19.20 ± 13.69 | 0.44 | 0.41¥ |
| FMI | 12.92 ± 3.09 | 12.67 ± 2.64 | 13.09 ± 3.12 | 0.67 | 0.64 |
| Biochemical variables | |||||
| TC (mmol/l) | 4.71 ± 0.88 | 4.92 ± 1.05 | 4.65 ± 0.86 | 0.21 | 0.53 |
| TG (mmol/l) | 0.89 ± 0.089 | 0.76 ± 0.099 | 0.63 ± 0.072 | 0.41 | 0.58 |
| HDL (mmol/l) | 1.16 ± 0.26 | 1.24 ± 0.29 | 1.22 ± 0.27 | 0.16 | 0.05 |
| LDL (mmol/l) | 2.37 ± 0.58 | 2.52 ± 0.66 | 2.45 ± 0.61 | 0.32 | 0.24 |
| IPAQ (MET min-week) | 1047.60 ± 1147.35 | 1000.15 ± 939.60 | 912.08 ± 1129.44 | 0.71 | 0.32 |
| N6 per N3 | 12.66 ± 0.10 | 12.65 ± 0.11 | 12.63 ± 0.10 | 0.17 | 0.36 |
| CSI | 12.13 ± 4.73 | 13.19 ± 6.04 | 12.85 ± 5.31 | 0.36 | 0.44 |
| HOMA index | 3.13 ± 1.09a | 3.71 ± 1.56b | 3.33 ± 1.23c,a,b | 0.25 | 0.01 |
| hs.CRP (mg/l) | 4.22 ± 4.67 | 3.87 ± 4.59 | 4.40 ± 4.56 | 0.80 | 0.33 |
BMI body mass index, FFM fat free mass, HDL high density lipoprotein, HOMA homeostatic model assessment, hs-CRP high-sensitivity C-reactive protein, SD standard deviation, T tertile, TC total cholesterol, TG triglyceride, VFL visceral fat level, IPAQ international physical activity questionnaires, FFMI fat-free mass index, FMI fat mass index, WC waist circumference, WHR waist to hip ratio.
Values are represented as means (SD).
†Calculated by analysis of variance (ANOVA).
P-value*: ANCOVA was performed to adjusted potential confounding factors (age, BMI, energy intake, Physical activity).
¥: BMI consider as a collinear variable for anthropometric measurements and these variables adjusted for Age, physical activity, and total energy intake.
p < 0.05 was considered significant.
Values in the same row with different superscript letters are significantly different.
Significant values are in bold.