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. 2023 Jul 27;14(7):475. doi: 10.1038/s41419-023-06008-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Heatmap of THOC gene expression levels in LUSC (n = 502) and normal tissues (n = 51) based on TCGA data. B Bar chart showing the difference in mean THOC expression levels between LUSC and normal tissues (right) and the specific expression levels of THOC3 in LUSC and normal tissues (left). C Heatmaps of THOC levels in LUSC datasets GSE157011 (n = 484) and GSE73403 (n = 69). D Venn diagram showing the three most highly expressed genes in the THOC family according to TCGA, GSE157011, and GSE73403. E DEPMAP analysis of the effects of THOC1/2/3/5/6/7 knockout on 22 LUSC cell lines (left) with THOC levels in 27 LUSC cell lines shown on the right. F Immunohistochemistry (IHC) staining of THOC3 in 90 pairs of LUSC tissues and adjacent normal tissues. Scale bars = 100 μm. G Kaplan-Meier plots of patients with high (H-score > 50) or low (H-score ≤ 50) THOC3 expression based on TMA results (top), and patients with H-score ≥ 80 or ≤50 based on TMA results (bottom). H THOC3 mRNA and protein expression levels in B2B, SK-MES-1, H1703, and H520 shown by qRT-PCR and WB. *P < 0.05; **P < 0.01; ***P < 0.001. Variables are presented as mean ± SD.