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. 2023 Feb 6;44(8):1612–1624. doi: 10.1038/s41401-023-01059-w

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© The Author(s), under exclusive licence to Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese Pharmacological Society 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 4 — a H&E staining and quantitative analysis of leukocytes (dark blue-purple monocytes) in the infarcted zone in the Sham-operated and SCNx mice on day 3 post-MI (Scale bars: 500 μm). b Gene expression levels of anti-inflammatory markers Il-10, Cd206, and Arg1 in the LV of Sham-operated and SCNx mice on days 0 and 3 post-MI (n = 6 per group). c Gene expression levels of pro-inflammatory markers Tnf-α, Il-1β, and iNOS in the LV of Sham-operated and SCNx mice on days 0 and 3 post-MI (n = 6 per group). d Western blot analysis of CD206, ARG1, IL-1β, and iNOS protein levels in infarcted hearts on day days 0 and 3 post-MI (n = 3 per group). e Relative densitometric quantification of CD206, ARG1, IL-1β, and iNOS protein levels in infarcted hearts on day 3 post-MI (n = 3 per group). f Representative immunofluorescence staining images and quantitative analysis showing iNOS⁺ and F4/80⁺ macrophages in the infarcted hearts of Sham-operated and SCNx mice on day 3 post-MI (Scale bars: 20 μm, n = 16 per group). g Representative immunofluorescence staining images and quantitative analysis showing CD206⁺ and F4/80⁺ macrophages in the infarcted heart of Sham-operated and SCNx mice on day 3 post-MI (Scale bars: 20 μm, n = 16 per group). h Flow cytometric analyses of the CD45⁺ CD11b⁺ Ly-6G^- F4/80⁺ CD206⁺ macrophages in the infarcted hearts of Sham-operated and SCNx mice (n = 4 per group). Data are presented as mean ± SEM; Student’s t-test or one-way ANOVA; *P < 0.05, **P < 0.01, ***P < 0.001, ns not significant.