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. 2023 Mar 7;44(8):1637–1648. doi: 10.1038/s41401-023-01067-w

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© The Author(s), under exclusive licence to Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese Pharmacological Society 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 1 — a Chemical structure of celastrol. b Representative IHC result of the expression levels of NLRP3, HSP90α, and HSP90β in the liver tissue from normal individuals, and HCV-HCC, HBV-HCC, and cirrhosis patients. Scale bar = 20 µm. c The expression level of each protein was scored semi-quantitatively by two researchers in blind, showing a strong correlation between NLRP3 and HSP90β in the liver tissues of normal individuals and HCC patients with HCV infection. The correlation analysis results are shown in Table 1.