Fig. 2. Loss of TP53 synergizes with c-MET to promote hepatocarcinogenesis in mice.
A Study design. B Gross images, H&E staining, and immunohistochemical staining of p53, CK19, HNF4a, and Ki67 in tumor lesions from c-MET/sgp53 mouse liver. C Western blotting analysis of lysates from normal liver and c-MET/sgp53 mouse HCCs. Scale bar: 200 μm (100×). H&E hematoxylin and eosin staining, CK19 cytokeratin 19, HNF4a hepatocyte nuclear factor 4α.