Fig. 7. Trametinib treatment decreases proliferation and induces apoptosis in c-MET/sgp53 HCC cell xenografts.

Ki67 and cleaved-caspase 3 (C-C3) indices, markers of proliferation and apoptosis, respectively, were assessed by evaluating the number of Ki-67 and C-C3 positive cells in at least 3000 tumor cells per sample. Three mice per group were analyzed. H&E hematoxylin and eosin staining. Scale bar: 100 µm (200×). Student’s t-test: **P < 0.001; *P < 0.05.