Table 3.

Univariate and multivariate Cox proportional regression analysis of factors associated with OS and DFS in all patients (N = 316)

Variables	Overall survival				Disease-free survival
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Age, > 50 years vs ≤ 50 years	1.138 (0.792–1.634)	0.484			1.116 (0.806–1.544)	0.510
Gender, male vs female	1.247 (0.746–2.085)	0.400			1.174 (0.732–1.882)	0.506
HBsAg, positive vs negative	0.996 (0.636–1.559)	0.985			1.115 (0.738–1.683)	0.605
Liver cirrhosis, yes vs no	0.795 (0. 539–1.173)	0.248			0.736 (0.519–1.043)	0.085
Child–Pugh score, B vs A	1.072 (0.523–2.197)	0.850			0.941 (0.479–1.846)	0.859
Edmonson stage, III-IV vs I-II	1.440 (1.004–2.066)	0.048	1.247 (0.860–1.809)	0.245	1.266 (0.914–1.754)	0.155
No. of tumors, multiple vs single	2.181 (1.498–3.177)	0.000	1.191 (0.783–1.811)	0.415	2.217 (1.575–3.122)	0.000	1.393 (0.954–2.033)	0.086
Largest tumor size, > 5 vs ≤ 5 cm	4.969 (3.004–8.219)	0.000	3.147 (1.840–5.384)	0.000	3.677 (2.457–5.504)	0.000	2.471 (1.600–3.816)	0.000
AFP, ≥ 400 vs < 400 ng/mL	1.917 (1.335–2.752)	0.000	1.354 (0.903–2.032)	0.143	2.010 (1.451–2.784)	0.000	1.516 (1.061–2.165)	0.022
BCLC stage, B-C vs 0-A	5.675 (3.186–10.111)	0.000			3.737 (2.409–5.799)	0.000
PVTT, yes vs no	5.650 (3.766–8.476)	0.000	3.078 (1.958–4.838)	0.000	4.326 (2.947–6.350)	0.000	2.622 (1.705–4.033)	0.000
Preoperative CTCs, ≥ 2 vs < 2	3.515 (2.435–5.074)	0.000	2.058 (1.364–3.105)	0.001	2.967 (2.121–4.151)	0.000	1.761 (1.196–2.592)	0.004