Fig. 1.

CTNNB1 expression allows the identification of HPV-positive HNSCC patients with longer overall survival. a Kaplan–Meier survival curve for patients with HPV-positive HNSCC extracted from the TCGA database and stratified according to the OTV of CTNNB1 into “low” and “high” group. b Respective CTNNB1 expression values per patient stratified into the two groups (“low” [blue] and “high” [orange]) according to the OTV (indicated as “Cutoff”) for OS. c Top—Distribution of CTNNB1 expression in the two patient groups Bottom—Standardized Log-Rank statistics across multiple CTNNB1 expression values, indicating that a cutoff of 15,094 yields the highest prognostic power. HPV human papillomavirus, TCGA The Cancer Genome Atlas, OTV optimized threshold value, grps groups