Table 8.

Observational studies with dioxins found in food

Participants/subjects and research design	Patients	Patient parameters	Outcomes/main conclusion of the study	References
Examined relationships of TCDD exposure with TTP (TTP, the monthly probability of conception within the first 12 months of trying) and infertility (12 months of trying to conceive)	981 women exposed to TCDD in a 1976 accident	Serum TCDD concentration and estimated TCDD concentration at pregnancy	TCDD exposure may be associated with decreased fertility in Seveso mothers and potentially in their daughters exposed in utero	[18]
To study the levels of biologically active dioxin-like substances in adipose tissue of patients with DIE	30 patients	Dioxin-like substances were analyzed in adipose tissue	The total toxic equivalence and concentrations of both dioxins and PCBs were significantly higher in patients with DIE	[83]

TCDD 2,3,7,8-tetrachlorodibenzo-p-dioxin, TTP Time to pregnancy, DIE deep infiltrating endometriosis, PCBs Polychlorinated biphenyls