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. 2023 Jul 19;9(8):e17400. doi: 10.1016/j.heliyon.2023.e17400

Table 1.

Summary of studies included in the present meta-analysis.

Authors Year Study design N Gender (M/F) Age Region Stage Treatment Line Cut-off value Outcomes NOS
Lihong 2019 Retrospective 102 87/15 62 Asia III-IV Nivo,
Pemb,
Toripa,
Sinti
un-selected 45 OS,PFS 7
Taichi 2020 Retrospective 24 7/17 64.5 (54.8–74.2) Asia III-IV Atezo >1 40 OS 5
Cipriano 2020 Retrospective 34 27/17 67 (34–79) Europe IV Immunotherapy un-selected 50 OS 4
Shi 2021 Retrospective 103 68/35 66 Asia III-IV Immunotherapy/Chemoimmunotherapy un-selected 45 OS,PFS 7
Cinzia 2021 Retrospective 44 26/18 70 (42–83) Europe III-IV Pemb 1 45.1 PFS 8
Taisuke 2021 Retrospective 36 31/5 68.5 Asia III-IV Chemoimmunotherapy 1 40 OS,PFS 6
Junichi 2021 Retrospective 73 52/21 70.9 (46–89) Asia III-IV Nivo, Pemb,Atezo un-selected 43 OS,PFS 7
Yuri 2021 Retrospective 34 29/5 72 (55–81) Asia IV Chemoimmunotherapy 1 40 OS,PFS 6
Na 2021 Retrospective 123 98/25 59.9 (48.6–71.2) Asia IV Nivo,
Pemb,
Sinti,
Camre,
Toripa
un-selected 46.05 OS,PFS 6
Cipriano 2021 Retrospective 52 42/10 NR Europe IV Immunotherapy un-selected 50 OS,PFS 4
Stares 2022 Retrospective 219 109/110 69 Europe III-IV Pemb 1 45 OS,PFS 8
Satomi 2022 Retrospective 237 187/187 69 (62–73) Asia IV Chemoimmunotherapy un-selected 40.35 OS,PFS 7
Naoki 2022 Retrospective 38 30/8 75 (45–86) Asia III-IV Pemb 1 40 PFS 6

N, number; M, male; F, female; NR, not reported; OS, overall survival; PFS, progression-free survival; Nivo, Nivolumab; Pemb, Pembrolizumab; Toripa, Toripalimab; Sinti, Sintilimab; Camre, Camrelizumab; Atezo, Atezolizumab; NOS, Newcastle-Ottawa quality assessment Scale.