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. 2023 Aug;165(2):374–390. doi: 10.1053/j.gastro.2023.04.038

Figure 5.

Figure 5

Recruited metaplasia-derived and cancer-derived fibroblasts facilitate dysplastic progression in metaplastic gastroids (GOs). (A) Immunofluorescence staining in human stomach sections for metaplasia marker CD44v9, dysplasia marker TROP2, and FbS1 marker PDGFRα with nuclear 4′,6-diamidino-2-phenylindole (DAPI). Scale bar: 100 μm and 50 μm for enlarged. Representative images of immunofluorescence staining in GO sections for metaplasia marker CD44v9 and dysplasia marker TROP2 (B) and quantification of positive GO cells for each marker (C). Scale bar: 100 μm.