Table 1.
Demographics and baseline clinical parameters of the study population
| Parameter | Total (N = 568) | No alerts (N = 198) | Time in alert <20% (N = 219) | Time in alert ≥20% (N = 151) |
|---|---|---|---|---|
| Male gender, n (%) | 453 (80) | 158 (80) | 171 (78) | 124 (82) |
| Age, years | 69 ± 10 | 68 ± 9 | 69 ± 10 | 71 ± 11* |
| Ischaemic aetiology, n (%) | 285 (50) | 95 (48) | 103 (47) | 87 (58)# |
| NYHA class | # | |||
| Class I, n (%) | 36 (6) | 16 (8) | 16 (7) | 4 (3) |
| Class II, n (%) | 351 (62) | 126 (64) | 131 (60) | 94 (62) |
| Class III, n (%) | 171 (30) | 52 (26) | 71 (32) | 48 (32) |
| Class IV, n (%) | 10 (2) | 4 (2) | 1 (0.5) | 5 (3) |
| LV ejection fraction, % | 32 ± 9 | 33 ± 9 | 32 ± 9 | 30 ± 8 |
| AF history, n (%) | 196 (35) | 38 (19) | 78 (36)* | 80 (53)*, # |
| AF on implantation, n (%) | 100 (18) | 14 (7) | 42 (19)* | 44 (29)*, # |
| Diabetes, n (%) | 167 (29) | 52 (26) | 71 (32) | 44 (29) |
| COPD, n (%) | 89 (16) | 29 (15) | 32 (15) | 28 (19) |
| Chronic kidney disease, $ n (%) | 153 (27) | 33 (17) | 63 (29)* | 57 (38)* |
| Hypertension, n (%) | 334 (59) | 118 (60) | 128 (58) | 88 (58) |
| Beta‐blocker use, n (%) | 520 (92) | 185 (93) | 196 (89) | 139 (92) |
| ACE‐I, ARB or ARNI use, n (%) | 536 (94) | 186 (94) | 211 (96) | 139 (92) |
| Diuretic use, n (%) | 506 (89) | 167 (84) | 193 (88) | 146 (97)*, # |
| Antiarrhythmic use, n (%) | 116 (20) | 22 (11) | 49 (22)* | 45 (30)* |
| CRT device, n (%) | 410 (72) | 137 (69) | 162 (74) | 111 (74) |
| Primary prevention, n (%) | 500 (88) | 181 (91) | 187 (85) | 132 (87) |
Patients are stratified according to the percentage of time in alert during follow‐up.
ACE, angiotensin‐converting enzyme; AF, atrial fibrillation; ARB, angiotensin II receptor blockers; ARNI, angiotensin receptor‐neprilysin inhibitor; COPD, chronic obstructive pulmonary disease; CRT, cardiac resynchronization therapy; LV, left ventricular; NYHA, New York Heart Association.
*
P < 0.05 versus no alerts.
#
P < 0.05 versus <20%.
$
Estimated glomerular filtration rate <60 mL/min/1.73 m2.