Table 3.

Hazard of relapse by poverty group

Variable	Univariate		Multivariable model 1		Multivariable model 2		Multivariable model 3
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P value
Poverty (reference: not in extreme poverty)
In extreme poverty	1.89 (1.00-3.55)	.05	1.95 (1.03-3.72)	.04	1.68 (0.86-3.28)	.1	1.69 (0.84-3.41)	.1
Age at study enrollment
Per year increase	1.09 (1.03-1.16)	.002	1.07 (1.00-1.15)	.05	1.07 (1.00-1.15)	.05	1.06 (0.99-1.14)	.1
Sex (reference: female)
Male sex	0.92 (0.54-1.57)	.7	-	-	-	-	-	-
Parental education (reference: >HS)
≤HS	1.55 (0.93-2.58)	.1	-	-	-	-	1.30 (0.75-2.26)	.4
NCI high risk (reference: standard risk)
High risk	2.05 (1.22-3.44)	.007	1.13 (0.56-2.25)	.7	1.15 (0.57-2.32)	.7	1.22 (0.60-2.46)	.6
Blast cytogenetics (reference: neutral)
Favorable	0.45 (0.24-0.84)	.01	0.58 (0.30-1.14)	.1	0.58 (0.29-1.13)	.1	0.60 (0.30-1.18)	.1
Unfavorable	0.83 (0.25-2.71)	.8	0.77 (0.24-2.52)	.7	0.76 (0.23-2.49)	.7	0.75 (0.23-2.47)	.6
Average 6MP dose intensity
Per unit increase	1.52 (0.57-4.00)	.4	-	-	-	-	-	-
Average MTXDI dose intensity
Per unit increase	0.97 (0.33-2.90)	.9	-	-	-	-	-	-
Time from maintenance to study entry
Per year increase	0.54 (0.28-1.01)	.06	0.5 (0.28-0.86)	.01	0.49 (0.28-0.86)	.01	0.47 (0.26-0.85)	.01
Race/ethnicity (reference: non-Hispanic White)
Asian	1.46 (0.63-3.36)	.4	-	-	1.20 (0.46-3.17)	.7	-	-
African-American or Black	2.50 (1.28-4.88)	.007	-	-	1.06 (0.44-2.57)	.9	-	-
Hispanic	0.98 (0.97-0.99)	.002	-	-	2.23 (1.12-4.42)	.03	-	-

Model 1 adjusts for age at study enrollment, NCI risk group, blast cytogenetics, and time from start of maintenance.

Model 2 adds race/ethnicity to model 1.

Model 3 removes race/ethnicity and adds parental education to model 1.