Table 4.

Hazard of relapse by poverty group in the MEMS subcohort

Variable	Univariate		Multivariable model 1		Multivariable model 2		Multivariable model 3
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P value
Poverty (reference: not in extreme poverty)
In extreme poverty	2.03 (0.88-4.70)	.09	2.27 (0.92-5.59)	.08	2.11 (0.85-5.22)	.1	1.87 (0.79-4.41)	.2
Age at study enrollment
Per year increase	1.11 (1.04-1.19)	.003	1.07 (0.98-1.18)	.1	1.06 (0.96-1.16)	.2	1.06 (0.96-1.17)	.2
Sex (reference: female)
Male sex	0.92 (0.54-1.57)	.7	-	-	-	-	-	-
NCI high risk (reference: standard risk)
High risk	2.35 (1.22-4.54)	.01	1.27 (0.52-3.12)	.6	1.31 (0.53-3.22)	.6	1.27 (0.50-3.25)	.6
Blast cytogenetics (reference: neutral)
Favorable	0.35 (0.15-0.82)	.02	0.46 (0.18-1.17)	.1	0.47 (0.18-1.22)	.1	0.46 (0.18-1.17)	.1
Unfavorable	0.97 (0.23-4.09)	.9	0.86 (0.20-3.61)	.8	0.95 (0.22-4.09)	.9	0.89 (0.21-3.86)	.9
Average 6MP dose intensity
Per unit increase	1.54 (0.62-3.83)	.4	-	-	-	-	-	-
Average MTXDI dose intensity
Per unit increase	1.22 (0.35-4.31)	.8	-	-	-	-	-	-
Time from maintenance to study entry
Per year increase	0.37 (0.17-0.82)	.02	0.37 (0.18-0.74)	.005	0.37 (0.17-0.77)	.008	0.36 (0.18-0.74)	.005
Race/ethnicity (reference: non-Hispanic White)
African-American or Black	1.72 (0.58-5.12)	.3	-	-	-	-	1.06 (0.34-3.32)	.9
Asian	0.92 (0.24-3.55)	.9	-	-	-	-	0.67 (0.15-2.97)	.6
Hispanic	2.66 (1.13-6.26)	.03	-	-	-	-	1.97 (0.77-5.04)	.2
Median adherence
Per unit increase	0.98 (0.97-0.99)	.002	-	-	0.99 (0.98-1.00)	.1	0.99 (0.98-1.00)	.2

Model 1 adjusts for age at study enrollment, NCI risk group, blast cytogenetics and time from start of maintenance.

Model 2 adds adherence to model 1.

Model 3 adds race/ethnicity to model 2.