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. 2023 Jul 27;6(7):e2326230. doi: 10.1001/jamanetworkopen.2023.26230

Table 3. Associations Between Urine Albumin-Creatinine Ratio Testing and Albuminuria Treatment (N = 149 554).

Albuminuria therapy Odds ratio (95% CI)a P value
Overall
ACEi or ARB use 2.39 (2.32-2.46) <.001
SGLT2i use 8.22 (7.56-8.94) <.001
Blood pressure control <130/80 mm Hg 1.07 (1.04-1.10) <.001
Blood pressure control <140/90 mm Hg 1.20 (1.16-1.23) <.001
No diabetes
ACEi or ARB use 2.00 (1.89-2.11) <.001
SGLT2i use 11.55 (5.80-23.00) <.001
Blood pressure control <130/80 mm Hg 0.98 (0.93-1.04) .56
Blood pressure control <140/90 mm Hg 1.08 (1.02-1.15) .01
Diabetes
ACEi or ARB use 1.76 (1.69-1.83) <.001
SGLT2i use 1.44 (1.32-1.57) <.001
Blood pressure control <130/80 mm Hg 1.02 (0.97-1.06) .47
Blood pressure control <140/90 mm Hg 1.13 (1.08-1.19) <.001

Abbreviations: ACEi, angiotensin converting enzyme inhibitor; ARB, angiotensin II receptor blocker; SGLT2i, sodium-glucose cotransporter 2 inhibitor.

a

All models are adjusted for age, sex, race/ethnicity, insurance type, smoking status, eGFR, heart failure, coronary artery disease, and prior stroke.