Table 2.
Experiment 1: awakenings and interviews, and achieved states, with mean measured drug plasma concentrations for those participants who achieved the state. ∗Four dexmedetomidine and four propofol experiments were terminated before UR3. R, responsiveness; sd, standard deviation; UR, unresponsiveness.
| UR1, N of interviews/UR1, N of achieved states (%) | UR1, mean drug concentration (sd) | UR2, N of interviews/UR2, N of achieved states (%) | UR2, mean drug concentration (sd) | UR3, N of interviews/UR3, N of achieved states (%) | UR3, mean drug concentration (sd) | R3, mean drug concentration (sd) | All R periods, N of interviews/all UR periods, N of achieved states (%) | |
|---|---|---|---|---|---|---|---|---|
| Both drugs | 29/39 (74.4) | 16/17 (94.1) | 31/31 (100) | 76/87 (87.4) | ||||
| Dexmedetomidine | 16/20 (80.0) | 1.80 (0.84) ng ml−1 | 14/15 (93.3) | 1.65 (0.38) ng ml−1 | 16/16∗(100) | 3.27 (1.32) ng ml−1 | 1.64 (0.64) ng ml−1 | 46/51 (90.2) |
| Propofol | 13/19 (68.4) | 1.48 (0.60) μg ml−1 | 2/2 (100) | 0.96 (0.20) μg ml−1 | 15/15∗(100) | 2.46 (0.77) μg ml−1 | 1.11 (0.28) μg ml−1 | 30/36 (83.3) |