Table 1:

Node types in Hetionet, including the abbreviation, number of nodes, and description for each of the 11 metanodes in Hetionet v1.0

Metanode	Abbreviation	Nodes	Description
Anatomy	A	402	Anatomical structures, excluding structures that are known not to be found in humans. From Uberon.
Biological Process	BP	11,381	Larger processes or biological programs accomplished by multiple molecular activities. From Gene Ontology.
Cellular Component	CC	1,391	The locations relative to cellular structures in which a gene product performs a function. From Gene Ontology.
Compound	C	1,552	Approved small-molecule compounds with documented chemical structures. From DrugBank.
Disease	D	137	Complex diseases, selected to be distinct and specific enough to be clinically relevant yet general enough to be well annotated. From Disease Ontology.
Gene	G	20,945	Protein-coding human genes. From Entrez Gene.
Molecular Function	MF	2,884	Activities that occur at the molecular level, such as “catalysis” or “transport.” From Gene Ontology.
Pathway	PW	1,822	A series of actions among molecules in a cell that leads to a certain product or change in the cell. From WikiPathways, Reactome, and Pathway Interaction Database.
Pharmacologic Class	PC	345	“Chemical/Ingredient,” “Mechanism of Action,” and “Physiologic Effect” FDA class types. From DrugCentral.
Side Effect	SE	5,734	Adverse drug reactions. From SIDER/UMLS.
Symptom	S	438	Signs and Symptoms (i.e., clinical abnormalities that can indicate a medical condition). From the MeSH ontology.