Figure 3.

a. Schematic of OFC-striatum projection. b. Recordings from a subpopulation of OFC neurons that project to the striatum (identified via optogenetic tagging), whose activity is sustained throughout the inter-trial-interval and represents integrated value of the previous choice. Figure reproduced from [51]. c. Clustered population raster of all recorded OFC neurons. The population presented in panel b. closely resembles the activity of the cluster marked “B.” Figure reproduced from [51]. d. Activity in a single cluster of OFC neurons whose activity is sustained throughout the inter-trial-interval and represents integrated value of the previous choice, and whose activity resembles that of the striatal-projecting neurons in panels b. Figure reproduced from [74]. e. Schematic of ALM circuits identified in a series of papers by the Svoboda laboratory. f. Histology showing the segregation of medulla and thalamus projecting neurons in layer 5 of ALM. Figure reproduced from [80]. g. (Left) choice selectivity in thalamus projecting and medulla projecting ALM neurons respectively throughout the sample and delay task periods. Only thalamus projecting neurons maintain choice selectivity during the delay period. (Right) medulla projecting neurons display movement selectivity after the go cue.