Table 2.
Individual values for miR-21, miR-210 values, and clinical outcome
| Patient | miR-21 | miR-210 | TTLP (d) | TTSP (d) | ||||
|---|---|---|---|---|---|---|---|---|
| ΔCт mean pre-therapy | ΔCт mean post-therapy | 2−ΔΔCт | ΔCт mean pre-therapy | ΔCт mean post-therapy | 2−ΔΔCт | |||
| Responders | ||||||||
| 1 | 6.08 | 6.61 | 0.69 | 5.14 | 5.62 | 0.72 | 581 | 949 |
| 2 | 6.55 | 7.63 | 0.48 | 5.18 | 8.66 | 0.09 | None | 1205 |
| 3 | 6.96 | 7.34 | 0.76 | 4.72 | 5.35 | 0.65 | None | 443 |
| 4 | 6.00 | 5.86 | 1.10 | 7.42 | 7.17 | 1.19 | 854 | 1178 |
| 5 | 5.66 | 6.26 | 0.66 | 4.87 | 5.26 | 0.76 | None | 940 |
| 6 | 7.29 | 8.66 | 0.39 | 7.20 | 5.70 | 2.83 | 1004 | 1004 |
| 7 | 6.38 | 7.27 | 0.54 | 5.02 | 5.76 | 0.60 | None | 749 |
| 8 | 6.45 | 6.64 | 0.87 | 4.65 | 5.34 | 0.62 | None | 1224 |
| 9 | 5.79 | 5.80 | 0.99 | 6.25 | 6.34 | 0.94 | None | 875 |
| 10 | 5.30 | 5.57 | 0.83 | 5.36 | 5.76 | 0.76 | None | 883 |
| 11 | 5.93 | 6.27 | 0.79 | 5.94 | 4.51 | 2.70 | 267 | 867 |
| 12 | 5.52 | 7.36 | 0.28 | 5.17 | 7.10 | 0.26 | None | 386 |
| Non-responders | ||||||||
| 13 | 6.53 | 5.59 | 1.92 | 5.34 | 5.06 | 1.21 | None | 457 |
| 14 | 6.94 | 6.76 | 1.13 | 4.82 | 4.35 | 1.39 | 182 | 351 |
| 15 | 7.03 | 6.26 | 1.70 | 4.62 | 5.26 | 0.64 | None | 457 |
| 16 | 6.02 | 7.49 | 0.36 | 5.82 | 7.46 | 0.32 | 93 | 275 |
| 17 | 7.38 | 5.24 | 4.38 | 5.22 | 9.08 | 0.07 | 225 | 475 |
| 18 | 4.66 | 5.14 | 0.72 | 5.80 | 5.40 | 1.32 | None | 183 |
| 19 | 5.94 | 5.59 | 1.27 | 5.62 | 5.29 | 1.26 | 138 | 442 |
| 20 | 6.16 | 7.51 | 0.39 | 5.02 | 4.60 | 1.33 | None | 475 |
| 21 | 5.76 | 5.31 | 1.36 | 5.37 | 10.48 | 0.03 | 490 | 592 |
| 22 | 7.74 | 6.59 | 2.22 | 3.58 | 7.47 | 0.07 | None | 155 |
| 23 | 5.92 | 4.56 | 2.57 | 4.20 | 4.57 | 0.77 | None | 34 |
| 24 | 7.02 | 5.13 | 3.70 | 7.12 | 4.55 | 5.96 | None | 312 |
TTLP, Time to limited progression; TTSP, Time to systemic progression; 2−ΔΔCт = [(Δт post-therapy) − (ΔCт pre-therapy)]; d: days