Table 1.

Baseline characteristics and partial laboratory data of participants in our study

Variables	Pulmonary cryptococcosis	Extrapulmonary cryptococcosis	P-value
Patients	55	16	N/A
Gender
Male	27 (49.09%)	11 (68.75%)	0.165
Female	28 (50.91%)	5 (31.25%)
Age (mean ± SD)	53.45 ± 12.47	54.75 ± 18.16
Smokinge	7	4	0.42
Exposure historya	8	4	0.55
Preexisting immunocompromised conditionsb	13 (23.64%)	12 (75%)	0.000153
Diabetes mellitus	4	4	0.127
Autoimmune disease	5	6	0.018
Chronic renal disease	2	3	0.127
Chronic hepatic diseases	1	1
Malignancies	4	2	0.88
Long-term usage of immunosuppressants or glucocorticoids	6	8	0.002
Immunosuppressants	2	0
Glucocorticoids	3	1
Immunosuppressants and glucocorticoids	1	7
HIV infection	0	1
Previous tuberculosis	2	0
History of organ transplantation	0	0
Hypertension	17	4	0.89
Symptoms	22 (40%)	14 (87.5%)	0.001
Fever	5	11	< 0.001
Headache	0	8	< 0.001
Respiratory symptomsc	22	3	0.12
Laboratory tests
Na+ (mmol/L)	140.49 ± 2.64	137.77 ± 4.72	0.041ξ
CRP > 5 mg/L	29.4% (10/34)	64.3% (9/14)	0.025
CRP value (mg/L)	--	--	0.012Ψ
Monocyte counts (/uL)	459.82 ± 167.28	363.12 ± 234.61	0.025Ψ

^aExposure to avian excreta or plants or pets or working as a farmer

^bPatients with at least one of the following comorbidities: uncontrolled diabetes mellitus, autoimmune disease, chronic renal or hepatic diseases, malignancy, long-term usage of immunosuppressants or glucocorticoids, human immunodeficiency virus (HIV) infection, tuberculosis, history of organ transplantation. Malignancy includes current malignant solid tumor or hematologic neoplasms

^cAt least one of the following presentations: cough with or without sputum, chest pain, dyspnea or hemoptysis

^eSmoking may be a risk factor for cryptococcosis as reported by previous studies

ξ Student’s t-test

Ψ Mann-Whitney U test