Table 2.
Etiological detection tests of patients with cryptococcosis
| Test items | Pulmonary cryptococcosis | Extrapulmonary cryptococcosis | ||
|---|---|---|---|---|
| Surgical | Nonsurgicalb | Intracranial cryptococcosis | Cryptococcemia | |
| Serum LFA | 40% (2/5) | 86.7% (13/15) | 100% (6/6) | 100% (1/1) |
| CSF LFA | -- | 0% (0/5) | 100% (5/5) | -- |
| Serum LA | 100% (1/1) | 100% (6/6) | -- | 100% (1/1) |
| CSF LA | -- | -- | 100% (2/2) | -- |
| Serum GXM | 100% (1/1) | 100% (7/7) | 100% (2/2) | -- |
| CSF culture | 0% (0/1) | 0% (0/2) | 45.5% (5/11) | -- |
| India ink test | 0% (0/2) | 0% (0/5) | 54.5% (6/11) | -- |
| Pathology | 100% (32/32) | 100% (23/23) | 100% (1/1) | -- |
| Blood culture | -- | -- | 0 (0/10) | 100% (5/5)a |
| Bone marrow culture | -- | -- | 0 (0/1) | 100% (1/1)a |
All the tests were conducted before antifungal therapy or surgical resection. All the data were presented as percentage (positive population/ total detected population). Among 11 patients with intracranial cryptococcosis, 5 didn’t have chest CT scan. None of EPC patients underwent pulmonary pathological and microbiological examinations to diagnose PC. Some subjects in PC/EPC group were positive for more than one tests. Detailed data can be obtained from the first author
--: Nobody in the cohort had specified test results
GXM: capsular polysaccharide glucuronoxylomannan
aOne patient has both blood culture and bone marrow culture positive for Cryptococcus
bNonsurgical PC patients were generally treated in respiratory ward and diagnosed via percutaneous lung biopsy