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. 2023 Jul 14;14:1215900. doi: 10.3389/fphys.2023.1215900

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Copyright © 2023 Johnson, Geesala, Zhang, Lin, M’Koma and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rat model of TNBS-induced Crohn’s-like colitis: effect of liquid diet treatment. (A) Outside view of rat colons and (B) mucosal surface view of distal colons. Rat model of Crohn’s-like colitis was induced by intracolonic instillation of TNBS (65 mg/kg in 250 μL of 40% ethanol) to the distal colon. When rats were fed with regular pellet food, TNBS treatment induced localized transmural inflammation (∼2 cm length) in the distal colon (site I), with a distended colon segment (site P) prior to the inflammation site and a non-distended segment (site D) distal to the inflammation site. However, when rats were fed exclusively with liquid diet (mimicking exclusive enteral nutrition), lumen distention in site P was eliminated.