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Direct and indirect effect of idebenone on the mitochondrial oxidative metabolism. COQ10: cofactor Q 10; Cyt c: cytochrome c; GSH: glutathione; SOD: superoxide dismutase; GPX: glutathione peroxidase; NQO1: NAD(P)H quinone oxidoreductase 1; NOX2: nicotinamide adenine dinucleotide phosphate oxidase 2; Nrf2: nuclear factor erythroid-derived 2-related factor 2.
