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Metabolic pathway of the generation of uric acid and its effects on vascular endothelium. Abbre-viations: ATP—adenosine triphosphate; ADP—adenosine diphosphate; AMP—adenosine mono-phosphate; XO—xanthine oxidase; O2−—superoxide anion; ROS—reactive oxygen species; eNOS—endothelium nitric oxide synthase.
