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Schematic presentation of the pathomechanism(s) underlying the reduced nephron number induced by glomerular hyperfiltration, hypertension, and nephron change. Abbreviations: GFR—glomerular filtration rate; FFSS—fluid flow-induced shear stress; PTS—pressure-induced tensile stress; Cox2—cyclooxygenase 2; PGE2—prostaglandin E2; EP2—prostanoid receptor; cAMP—cyclic adenosine monophosphate; and GS—glomerular sclerosis.
