Table 1.
Comparison of the expression levels for selected proteins of the different OXPHOS components in hippocampus and neocortex of Mecp2−/y and WT mice. None of the differences were statistically significant (see p-values; degrees of freedom df = 10 for all comparisons; SD = standard deviation).
| Protein | Hippocampus | Neocortex | ||||
|---|---|---|---|---|---|---|
| Relative Units (Mean ± SD) |
p-Value | Relative Units (Mean ± SD) |
p-Value | |||
| WT | Mecp2−/y | WT | Mecp2−/y | |||
| NADH: ubiquinone oxidoreductase subunit B8 (NDUFB8), complex I | 1.35 ± 0.11 | 1.17 ± 0.23 | 0.12 | 0.78 ± 0.15 | 0.85 ± 0.21 | 0.51 |
| Succinate dehydrogenase complex iron sulfur subunit B (SDHB), complex II | 0.44 ± 0.07 | 0.50 ± 0.17 | 0.42 | 0.87 ± 0.11 | 0.92 ± 0.16 | 0.7 |
| Ubiquinol-cytochrome C reductase core protein 2 (UQCRC2, alternate name cytochrome B-C1 complex subunit 2), complex III | 0.44 ± 0.16 | 0.53 ± 0.16 | 0.32 | 1.05 ± 0.11 | 1.06 ± 0.13 | 0.9 |
| Cytochrome c oxidase subunit 1 (MTCO1), complex IV | 0.27 ± 0.04 | 0.29 ± 0.05 | 0.43 | 0.87 ± 0.13 | 0.85 ± 0.16 | 0.84 |
| ATP synthase F1 subunit alpha (ATP5A), FoF1 ATP synthase complex | 0.61 ± 0.12 | 0.68 ± 0.20 | 0.73 | 1.11 ± 0.08 | 1.09 ± 0.13 | 0.74 |