Table 3.
Glucosinolates effects on GSH metabolism.
| Glucosinolates | Effects on GSH Metabolism | Model | References |
|---|---|---|---|
| ITCs | Increase Phase II detoxification enzymes | In vitro and in vivo | [127,128] |
| ITCs | Decrease GSH levels | In vitro | [13,128,129] |
| ITCs | Increase γGLCL and GS activity | HepG2 cells | [13,130,131] |
| SFN | Modulation of Nrf2/GPX4 pathway | In vitro and in vivo | [130,131,132] |
| ITCS | Hormetic effects on cell proliferation and tumor growth through GSH levels modulation | HepG2, MDA-MB-231, MCF-7, HT1376 cells and in vivo | [133,134,135] |