Table 1.
Demographic data and smoking history.
| Dose groupa | Age (years) | BMI (kg/m2) | Smoking history | ||||
|---|---|---|---|---|---|---|---|
| N | Arith. mean | Range | Arith. mean | SD | Never/former/current | ||
| Part A (postmenopausal women) | 3 mg QD | 5 | 57.0 | 52-64 | 23.3 | 4.42 | 4/1/- |
| 30 mg QD | 7 | 56.6 | 52-60 | 24.6 | 1.91 | 4/3/- | |
| 60 mg BID | 7 | 61.7 | 52-68 | 24.2 | 1.69 | 4/3/- | |
| 90 mg QD | 7 | 62.3 | 57-67 | 24.1 | 2.43 | 5/2/- | |
| Placebo | 7 | 62.3 | 59-67 | 25.9 | 2.11 | 4/3/- | |
| Total | 33 | 60.2 | 52-68 | 24.5 | 2.52 | 21/12/- | |
| Part B (premenopausal women) | 60 mg QD | 9 | 40.4 | 32-48 | 24.6 | 2.61 | 4/1/4 |
| 60 mg BID | 9 | 38.4 | 32-46 | 23.4 | 3.02 | 1/4/4 | |
| Total | 18 | 39.4 | 32-48 | 24.0 | 2.81 | 5/5/8 | |
Abbreviations: BID, twice daily; BMI, body mass index; N, number of participants; QD, once daily; SD, standard deviation.
a
mg specifications refer to the doses of BAY1128688 administered (single doses).