Figure 3.

Lactosomal nanophotosensitizer mediated photodynamic treatment. Lactosomal nanophotosensitizer is designed by the incorporation of a polypeptide and photosensitizer conjugated with siRNAs. The lactosomal nanophotosensitizer upon administration is subjected to irradiation due to which the bound siRNAs are released and are responsible for radiation resistance gene silencing. The nanophotosensitizer is also responsible for the generation of ROS which promotes apoptosis. Additionally, phototreatment also induces the overexpression of ALA peptide resulting in ALA-mediated cell cytotoxicity.