Table 2.

Prevalence of glucocorticoid withdrawal symptoms in the first 12 weeks following surgical remission of endogenous hypercortisolism.

Symptom	Percentage of patients experiencing symptoma (%)					P-valueb
	Baseline	Weeks 1-4	Weeks 5-8	Weeks 9-12	Weeks 1-12	Baseline vs weeks 1-4	Weeks 1-4 vs weeks 9-12	Baseline vs weeks 9-12
Fatigue	56.8	43.2	44.2	46.8	44.7	.007	.811	.076
Myalgias and arthralgias	64.0	38.1	53.1	60.4	50.3	<.001	<.001	.586
Weakness	44.4	22.0	37.2	42.3	33.6	<.001	<.001	.838
Sleep disturbance	50.4	29.7	31.9	26.1	29.2	<.001	.785	<.001
Mood changes	40.8	16.9	19.5	21.6	19.3	<.001	.536	<.001
Headaches	40.0	23.7	14.2	12.6	17.0	.001	.015	<.001
Sweating	41.5	11.9	13.3	14.4	13.2	<.001	.889	<.001
Inability to concentrate	34.4	13.6	12.4	12.6	12.9	<.001	.785	<.001
Nausea	16.8	7.6	11.5	9.9	9.6	.009	.703	.092
Light-headedness	13.6	7.6	8.0	3.6	6.4	.203	.334	.020
Limited ability to work	34.4	37.3	29.2	32.4	33.0	.887	.555	.920
Predisposition to illness	35.2	28.0	35.4	37.8	33.6	.159	.061	.945

^aA particular symptom was considered present if reported on at least 50% of the weekly surveys during the specified time interval.

^bStatistical comparisons were made using logistic mixed effects models.