Table 3.
Quality of life and muscle function measurements before and 12 weeks after surgical remission of hypercortisolism.
| Presurgical baseline | 12 weeks after surgery | Difference | P-valuea | |
|---|---|---|---|---|
| SF-36 | ||||
| Physical functioning | 36.9 (14.6) | 37.3 (13.3) | −0.4 (10.3) | .725 |
| Role–physical limitation | 35.3 (12.5) | 33.4 (10.4) | −2.2 (11.3) | .062 |
| Body pain | 43.4 (11.9) | 39.3 (10.6) | −4.3 (10.7) | <.001 |
| General health | 37.0 (11.9) | 38.4 (10.9) | 0.7 (8.0) | .392 |
| Social functioning | 37.1 (13.0) | 38.5 (12.0) | 0.5 (12.9) | .720 |
| Role–emotional limitation | 39.0 (12.7) | 39.1 (13.1) | −1.0 (13.7) | .406 |
| Vitality | 35.1 (10.5) | 35.1 (9.9) | −0.3 (11.4) | .791 |
| Mental health | 40.6 (11.8) | 43.8 (11.9) | 2.6 (10.7) | .018 |
| Physical Component Summary score | 37.2 (13.1) | 35.0 (11.9) | −2.6 (10.1) | .015 |
| Mental Component Summary score | 38.6 (12.5) | 41.1 (12.2) | 1.5 (12.3) | .225 |
| CushingQoL | ||||
| Physical score | 40.8 (21.8) | 45.9 (22.8) | 5.4 (19.4) | .009 |
| Psychosocial score | 36.1 (24.2) | 50.8 (22.4) | 14.2 (22.8) | <.001 |
| Overall Cushing score | 39.8 (20.6) | 47.1 (21.1) | 7.8 (17.8) | <.001 |
| Muscle function | ||||
| Hand grip (nondominant hand), Z-scoreb | −0.10 (0.97) | −0.52 (1.14) | −0.37 (0.88) | .009 |
| Sit-to-stand test performance, Z-scoreb | −0.67 (1.41) | −0.23 (1.85) | 0.50 (1.23) | .013 |
Abbreviation: SF-36, Short-Form-36.
a
Paired t-tests were used to compare measurements at presurgical baseline and 12 weeks after successful surgery for hypercortisolism. Values are expressed as means (standard deviation). Short-Form-36 and CushingQoL scores were standardized to range from 0 to 100, with higher scores corresponding with higher self-reported quality of life. Muscle function was reported using age- and sex-adjusted Z-scores based on normative data from a reference US adult population.
b
Pre- and postsurgical measurements were available for n = 43 (handgrip strength) and n = 40 (sit-to-stand test).