Table 4.
Change in quality of life and muscle function measurements before and 12 weeks after surgical remission of hypercortisolism, stratified by baseline Cushing syndrome clinical disease severity.
| Mild Clinical disease severitya |
Moderate Clinical disease severitya |
Severe Clinical disease severitya |
P-valueb | |
|---|---|---|---|---|
| n = 47 | n = 39 | n = 43 | ||
| SF-36, delta (12 weeks-baseline) | ||||
| Physical functioning | −0.78 (10.70) | −2.26 (11.15) | 1.78 (8.79) | .091 |
| Role–physical limitation | −2.51 (13.56) | −5.22 (11.85) | 0.98 (6.10) | .097 |
| Body pain | −2.46 (10.48) | −8.51 (12.31) | −2.88 (8.65) | .074 |
| General health | −0.66 (7.17) | 0.42 (8.20) | 2.56 (8.70) | .292 |
| Social functioning | −2.24 (12.67) | −1.80 (10.28) | 5.66 (13.89) | .072 |
| Role–emotional limitation | −5.34 (13.79) | 1.81 (13.41) | 1.70 (12.73) | .061 |
| Vitality | −0.97 (12.36) | 0.16 (11.16) | 0.08 (10.56) | .994 |
| Mental health | 2.35 (9.20) | 1.72 (10.16) | 3.65 (12.82) | .812 |
| Physical Component Summary | −1.77 (10.13) | −6.13 (11.85) | −0.49 (7.88) | .132 |
| Mental Component Summary | −1.52 (11.78) | 3.16 (10.12) | 3.76 (14.06) | .199 |
| CushingQoL, delta (12 weeks-baseline) | ||||
| Physical score | 5.48 (19.80) | 14.66 (20.85) | 22.98 (24.48) | .009 |
| Psychosocial score | 6.72 (20.05) | 2.87 (18.27) | 6.31 (20.01) | .928 |
| Overall CushingQoL | 6.38 (17.36) | 5.82 (16.86) | 10.87 (19.09) | .555 |
| Muscle function (12 weeks-baseline) | ||||
| Hand grip (nondominant hand), Z-scorec | 0.17 (0.26) | −0.19 (1.06) | −0.82 (0.69) | .002 |
| Sit to stand test performance, Z-scorec | 1.01 (1.62) | 0.38 (1.20) | 0.41 (1.10) | .830 |
Abbreviation: SF-36, Short-Form-36.
Clinical disease severity scores were calculated for each patient prior to surgical treatment for hypercortisolism. A total score of 1-8 points was considered mild, 9-14 points moderate, and 15-22 points severe clinical disease.
Kruskal–Wallis test was used to compare the change in quality of life and muscle function measurements (12 weeks-baseline) across the different Cushing syndrome clinical disease severity groups. Values are expressed as means (standard deviation).
Pre- and postsurgical measurements were available for n = 43 (handgrip strength) and n = 40 (sit-to-stand test).