Table 4.
LD50 value of berberine via IV, IP, and IG administration.
| Compound | LD50 | References | ||
|---|---|---|---|---|
| IV | IP | IG | ||
| Berberine hydrochloride | 9.04 ± 0.8 mg/kg | 57.61 ± 23.32 mg/kg | LD50 not found; 20.8 g/kg (safe dose) 41.6 g/kg (toxic dose) |
[79] |
| - | - | 2.83 ± 1.21 g/kg | [81] | |
| Berberine from Rhizoma coptidis | - | - | 713.57 mg/kg (0.713 g/kg) |
[80] |
| Powdered root B. vulgaris | - | - | 2.60 g/kg | [82] |
| Extract of B. vulgaris | - | - | 1.28 g/kg | [82] |
| Berberine sulphate | - | 205 mg/kg | - | [82] |
| Berberine | - | 23 mg/kg | - | [82] |
IV, intravena; IP, intraperitoneal; IG, oral intragastric.