Figure 4.

Molecular docking analysis between Aβ peptide (1–42) (PDB ID:1Z0Q) and PIC or its analogs. (A) The docking poses of piceatannol (PIC, lime-green), gnetol (GNT, blue-green), resveratrol (RSV, magenta), rhapontigenin (RHA, yellow), and isorhapontigenin (isoRHA, purple) in the same segment of Aβ peptide (1–42) helix (gray). (B) The docking pose of PIC in the segment of Aβ peptide (1–42) helix. Superimposed docking poses of (C) GNT and PIC, and (D) RHA and PIC in a segment of Aβ peptide (1–42) helix. Hydrogen bonds were represented as green dash lines. Residues are labeled as shown. The figures were created using Pymol.