Figure 6.

Effects of piceatannol pre-treatments on improvements of cognitive dysfunctions in scopolamine-induced amnesiac ICR mice. (A) The preventive protocol of PIC pre-treatment once a day (50 mg/kg) for 7 days before a learning behavior evaluation and donepezil (5 mg/kg) was used as the positive control. (B) The step-through latency (s) of mouse in a two-day trial of the passive avoidance test, the first day was the acquisition trial and the second day was the retention trial. (C) The AChE activity in the brain extracts of the blank and the treated groups. Multiple group comparisons were performed using one-way analysis of variance (ANOVA) and the post hoc Tukey’s test, and the different lowercase alphabet letters (for the acquisition trial) or uppercase alphabet letters (for the retention trial or the AChE activity in the brain extracts) in each bar were considered significantly different (p < 0.05).