Table 3.
GRADE summary of outcomes for EG versus CG for patients with MetS.
| Outcomes | No. of participants(studies) | Anticipated absolute effects (95% CI) |
Relative effect (95% CI) | Certainty of the evidence (GRADE) | |
|---|---|---|---|---|---|
| Risk with CG | Risk difference with EG | ||||
| WC | 369 (7) | The mean WC ranged from 95.9 to 107.85 | The mean WC in the EG was 2.16 lower (3.78 to 0.54 lower) | – | ⊕⊕○○ LOWa,b |
| FBS | 576 (9) | The mean FBS ranged from 96.28 to 182.1 | The mean FBS in the EG was 8.6 lower (15.46 to 1.74 lower) | – | ⊕⊕○○ LOWa,c |
| DBP | 383 (5) | The mean DBP ranged from 76.18 to 85.1 | The mean DBP in the EG was 2.8 lower (4.53 to 1.06 lower) | – | ⊕⊕○○ LOWa,b |
| SBP | 405 (6) | The mean SBP ranged from 108.11 to 152.7 | The mean SBP in the EG was 4.82 lower (9.98 to 0.35 lower) | – | ⊕⊕○ LOWa,c |
| TG | 476 (8) | The mean TG ranged from 26.28 to 224.09 | The mean TG in the EG was 1.28 higher (3.75 lower to 6.3 higher) | – | ⊕⊕⊕○ MODERATE a |
| HDL-C | 476 (8) | The mean HDL-C ranged from 25.74 to 49.42 | The mean HDL-C in the EG was 1.28 higher (2.58 to 7.38 higher) | – | ⊕⊕○○ LOWa,c |
| IL-6 | 122 (2) | The mean IL-6 ranged from 1.81 to 18.68 | The mean IL-6 in the EG was 1.50 lower (3.97 lower to 0.97 higher) | – | ⊕○○○VERY LOWa,b,c |
| TNF-a | 122 (2) | The mean TNF-a ranged from 36.52 to 78.9 | The mean TNF-a in the EG was 12.97 lower (18.37 to 7.57 lower) | – | ⊕○○○ LOWa,b |
| CRP | 130 (2) | The mean CRP ranged from 2.31 to 2.8 | The mean CRP in the EG was 1.24 lower (1.71 to 0.77 lower) | – | ⊕⊕○○ LOWa,b |
| hsCRP | 143 (2) | The mean hsCRP ranged from 1.006 to 1.49 | The mean hsCRP in the EG was 1.10 lower (4.35 lower to 2.16 higher) | – | ⊕○○○ VERY LOWa,b,c |
| MDA | 165 (3) | The mean MDA ranged from 2.81 to 19.78 | The mean MDA in the EG was 2.35 lower (4.47 to 0.24 lower) | – | ⊕○○○ VERY LOWa,b,c |
CG, control group; CI, confidence interval; EG, experimental group.
a
Poor methodology including the method of randomization, allocation concealment, and blinding.
b
Small sample sizes.
c
I2 ≥ 50% for heterogeneity.
⊕:Meets the quality of evidence rating. ○:Does not meet the quality of evidence rating.