Table 1.

A global comparison of CDI burden and epidemiology in different regions of the world.

Nation/Region	Incidence of CDI	Reference
United States	Incidence of 101.3 [CA (51.2) and HA (50.1)] cases per 100,000 persons in 2020; incidence of 148.55 [CA (65.81) and HA (82.74)] cases per 100,000 persons in 2015	CDC 2020 [28]
Canada	National rate of HA-CDI decreased from 5.9 to 4.3 per 10,000 patient days from 2009 to 2015	Katz et al. [38]
Europe	Mean incidence of CDI was 3.48 cases per 10,000 patient days in 2016–2017; 60.9% HA, 32.7% CA, and 6.7 rCDI	ECDC 2022 [46]
Australia	HA-CDI 3.94 per 10,000 patient bed days in 2013 and 4.05 per 10,000 patient bed days in 2018	ACSQHC 2020 [55]
Asia	Pooled incidence rate at 5.3 per 10,000 patient days	Collins et al. [81]