Table 2.

Association between AF diagnosis and MACE according to risk quartile.

	Q4	No-AF	New AF	HR AF/Q4	HR AF/No-AF
N	10,239	37,723	2574
Age (average ± SD)	84.8 ± 6.7	77.65 ± 8.4	81.2 ± 7.9
AF (n) Incidence/1000 people-years [CI95%]	1148 17 [16.1–18.1]	-	2574 8.9 [8.6–9.2]
Chronic kidney disease (n %) Incidence/1000 people-years [CI95%]	2748 (26.83%) 40.8 [39.3–42.3]	5158 (13.67%) 20.3 [19.8–20.9]	676 (26.26%) 40.1 [37.1–43.2]	0.98 [0.90–1.06] p = 0.706	1.97 [1.82–2.13] p < 0.001
Cognitive impairment (n %) Incidence/1000 people-years [CI95%]	1569 (15.32%) 23.3 [22.1–24.5]	3471 (9.2%) 13.7 [13.2–14.1]	310 (12.04%) 18.4 [16.4–20.6]	0.78 [0.69–0.89] p = 0.002	1.34 [1.2–1.51] p < 0.001
Heart failure (n %) Incidence/1000 people-years [CI95%]	1853 (18.1%) 27.5 [26.3–28.8]	2096 (5.56%) 8.3 [7.9–8.6]	676 (26.26%) 40.1 [37.1–43.2]	1.45 [1.33–1.6] p < 0.0001	4.85 [4.5–5.3] p < 0.0001
Ischemic heart disease (n %) Incidence/1000 people-years [CI95%]	1479 (14.44%) 22.0 [20.8–23.1]	2558 (6.78%) 10.1 [9.7–10.5]	367 (14.26%) 21.8 [19.6–24.1]	0.99 [0.88–1.11] p = 0.908	2.16 [1.93–2.41] p < 0.001
Stroke/transient ischemic attack (n %) Incidence/1000 people-years [CI95%]	459 (4.48%) 6.8 [6.2–7.5]	698 (1.85%) 2.7 [2.5–3.0]	187 (7.26%) 11.1 [9.6–12.8]	1.62 [1.37–1.92] p < 0.001	4.03 [3.43–4.74] p < 0.001
Peripheral arteriopathy (n %) Incidence/1000 people-years [CI95%]	1347 (13.15%) 20.0 [18.9–21.1]	2431 (6.44%) 9.6 [9.2–10.0]	345 (13.4%) 20.5 [18.4–22.7]	1.02 [0.90–1.15] p = 0.724	2.13 [1.90–2.4] p < 0.001
Death (n %) Incidence/1000 people-years [CI95%]	2861 (27.94%) 42.5 [40.9–44.0]	6799 (18.02%) 26.8 [26.1–27.4]	518 (20.12%) 30.7 [28.1–33.5]	0.72 [0.65–0.79] p < 0.001	1.14 [1.04–1.25] p = 0.027
Total MACE (n%) Incidence/1000 people-years [CI95%]	3791 (37.02%) 56.3 [54.5–58.1]	5352 (14.11%) 21.1 [20.5–21.6]	1748 (67.9%) 73.0 [68.9–77.1]	1.29 [1.21–1.38] p < 0.001	3.52 [3.31–3.75] p < 0.001