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. 2023 Jul 19;12(7):1454. doi: 10.3390/antiox12071454

Figure 6.

Figure 6

Effects of ROCK inhibitors and AT1 receptor blockers in the cholesterol biosynthesis marker HMGCR. The increase in HMGCR protein levels induced by dyskinesia (6-OHDA + LD, green bars) is reduced via the co-administration of L-DOPA and the ROCK inhibitor fasudil, (6-OHDA + LD + fasudil, blue bars) in the substantia nigra (A) and the striatum (C). Co-treatment with L-DOPA and the AT1 receptor antagonist candesartan (6-OHDA + LD + candesartan, blue bars) also produces a significant reduction in HMGCR protein levels induced through dyskinesia in the substantia nigra (B) and the striatum (D). The results were normalized to the values of 6-OHDA-lesioned animals treated with saline. Data are mean ± standard error of the mean (SEM); * p < 0.05, significant differences relative to 6-OHDA-lesioned rats; $ p < 0.05 significant differences relative to L-DOPA-treated rats. One-way ANOVA and Holm–Sidak post hoc test were used.