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. 2023 Jul 26;43(30):5432–5447. doi: 10.1523/JNEUROSCI.0208-22.2023

Figure 8.

Figure 8.

Long-lasting PKCδ activity does not regulate ERK. A, Schematic of experimental design B, The time course of ERK activity as measured by the mean change in the lifetime of the EKAR sensor in the primary dendrite after 5 spine stimulation. ERK activity was compared when either vehicle (n (neurons) = 9) or 1NM-PP1 (n = 8) was added 10 min after the end of the stimulation to inhibit long-lasting PKCδ activity or when activation of ERK was blocked by bath application of U0176 (n = 8). Mixed affects analysis **p = 0.009 fixed effect by drug treatment F(2,22) = 5.874. C, Quantification of mean change in lifetime at the time indicated by gray shading in B. p = 0.033 one way ANOVA (F(2,22) = 4.00). *p = 0.034, ns p = 0.98 comparing indicated groups (Sidak's post test).