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. 2023 Jun 29;11(7):1856. doi: 10.3390/biomedicines11071856

Figure 2.

Figure 2

Impact of inhibition of PI3K/AKT/mTOR and MAPKs signaling pathways on the protective effect of FGF1 and EGF against taltobulin. The viability of MCF-7 cells treated with 5 nM TLT and various chemical inhibitors targeting key signaling pathways (20 µM LY294002 for PI3K, 20 µM UO126 for MEK1/2, and a mixture of 20 µM LY294002 and 20 µM UO126 for both PI3K and MEK) was measured after 48 h in the presence or absence of 10 ng/mL FGF1 or EGF using the alamarBlue assay. Data were normalized to untreated cells and are presented as mean values ± standard deviation (SD) from three independent experiments. Statistical significance: ** p < 0.01, *** p < 0.001, no significant differences indicated as ‘ns’.