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Potential mechanism of FGF1 and EGF action in protecting MCF-7 cells against taltobulin. Both FGF1 and EGF, upon activation of their receptors (FGFR or EGFR), protect MCF-7 cells via the MEKs/ERKs pathway, and MEK1/2 inhibition by UO126 blocks this action. However, in the case of FGF1, alternatively, protection of MCF-7 cells against taltobulin can occur through activation of the AKT/mTOR pathway, which then reactivates ERKs.
