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. 2023 Jul 7;11(7):1937. doi: 10.3390/biomedicines11071937

Figure 1.

Figure 1

A graphical representation of the workflow. Data Aggregation: SARS-CoV-2 epitopes were extracted from IEDB, and human antigens that are implicated in enteric ADs were depicted. UniProt was searched to retrieve proteins sequences of the enteric self-antigens. Sequence Alignment: Emboss Matcher was employed; 58 Similar Sequences were found with a cut-off of at least 6 identical AAs and peptide length > 7. Data Validation: IEDB was searched to validate that the assayed enteric epitopes harbor those peptide sequences. Out of those, 10 were part of antigens that were previously identified to cross-react with SARS-CoV-2 antigens.