Table 1.
Sequence similarity between SARS-CoV-2 proteins and enteric self-antigens related to ADs.
| Human Protein (Autoimmune-Related Disease) 1 |
SARS-CoV-2 Protein |
Human vs. SARS-CoV-2 |
Ln | Identity % | Similarity % | Score 2 |
|---|---|---|---|---|---|---|
|
Cytochrome P450 2D6
(AIH, CD) |
Membrane glycoprotein |
KKSLEQW | 7 | 85.7 | 85.7 | 33 |
| KKLLEQW | ||||||
|
Keratin,
type I cytoskeletal 18 (AIH) |
Spike glycoprotein |
VSETNDTK | 8 | 75 | 75 | 26 |
| VSGTNGTK | ||||||
| Spike glycoprotein |
EELDKYW | 7 | 85.7 | 100 | 33 | |
| EELDKYF | ||||||
| nucleocapsid phosphoprotein |
NARIVLQI | 8 | 75 | 87.5 | 28 | |
| NAAIVLQL | ||||||
|
Myosin-11
(AIH) |
Envelope small membrane protein | VKNDNSSR | 8 | 87.5 | 87.5 | 30 |
| VKNLNSSR | ||||||
| Actin, alpha skeletal muscle (AIH) | Spike glycoprotein |
GDGVTHNV | 8 | 75 | 75 | 28 |
| GIGVTQNV | ||||||
| Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PBC) | Spike glycoprotein |
ATRFAAAY | 8 | 75 | 87.5 | 32 |
| ATRFASVY | ||||||
| Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (PBC) | Spike glycoprotein |
PATPAGPK | 8 | 75 | 75 | 32 |
| PATVCGPK | ||||||
| Spike glycoprotein |
DVPIGAIIC | 9 | 77.8 | 88.9 | 39 | |
| DIPIGAGIC | ||||||
| Histone H1.0 (UC) | Nucleocapsid phosphoprotein |
PKKAKKPK | 8 | 75 | 75 | 29 |
| PKKDKKKK |
1 Human proteins that are implicated in enteric autoimmune diseases: autoimmune hepatitis (AIH), celiac disease (CD), primary biliary cholangitis (PBC), and ulcerative colitis (UC). 2 Score is based on BLOSUM62 substitution matrix between amino acids.