Table 1.
Demographic characteristics of study participants and the concentrations of cerebrospinal fluid biomarkers in mild cognitive impairment and healthy controls (HC: healthy control, MCI: mild cognitive impairment, SD: standard deviation, T-tau: total tau, P-tau: phosphorylated tau 181, Aβ-42: amyloid β 42, Aβ-40: amyloid β 40, CDR: Clinical Dementia Rating, MoCA: Montreal Cognitive Assessment).
| Sample Type | CSF | ||
|---|---|---|---|
| Participants | HC (n = 48) | MCI (n = 38) | p-Value |
| Age (mean ± SD) | 68.92 ± 6.14 | 75 ± 9.51 | 0.0003 |
|
Sex
(% female) |
54.16% | 55.30% | Not significant |
| Years of Education (mean ± SD) | 16.2 ± 2.29 | 16.31 ± 2.75 | Not significant |
| Ethnicity | Caucasian: 85.4%, African American: 14.6%, Asian: 0% |
Caucasian: 95%, African American: 5%, Asian: 0% |
Not significant |
| Sum of Boxes CDR (mean ± SD) | 0.05 ± 0.25 | 2.80 ± 1.35 | <0.0001 |
| Global CDR (mean ± SD) | 0.0 ± 0.0 | 0.5 ± 0.0 | <0.0001 |
| MoCA (mean ± SD) | 26.48 ± 2.60 | 21.49 ± 4.86 | <0.0001 |
| p-tau181 (mean ± SD) | 33.31 ± 9.48 | 85.8 ± 47.3 | <0.0001 |
| T-tau (mean ± SD) | 267.0 ± 197 | 587.4 ± 312.3 | <0.0001 |
| Aβ1–42 (mean ± SD) | 1169.7 ± 384.7 | 723.6 ± 413.0 | <0.0001 |
| Aβ1–40 (mean ± SD) | 12,190 ± 3356.6 | 12,657.0 ± 4978.9 | Not significant |
| Aβ1–42/Aβ1–40 | 0.0956 ± 0.015 | 0.058 ± 0.020 | <0.05 |
| Apoe4 Genotype | 21% | 58% | <0.05 |