| Oshima [20] |
A total of 49 patients with resectable or borderline resectable PDAC after NACRT were included. A cut-off value of 0.077 for CAR was determined. The group with CAR > 0.077 lost more body weight during NACRT (p = 0.03). Higher CAR was associated with significantly shorter overall survival.
|
| Wijk [21] |
A total of 163 patients with resected PDAC were included. A cut-off value of 0.2 for CAR was determined. CAR ≥ 0.2 was associated with decreased overall survival (16 vs. 26 months, p = 0.003). Higher CAR was an independent indicator of decreased overall survival.
|
| Murakawa [22] |
A total of 117 patients with resectable PDAC were included who had radiacal surgery with S1 adjuvant chemotherapy. A cut-off value of 0.036 for CAR was determined. The 5-year overall survival (OS) rates in the high- and low-ratio groups were 22.5% and 36.4%, respectively (p = 0.0089). The 5-year disease-free survival rates in the high- and low-ratio groups were 12.5% and 22.1%, respectively (p = 0.0097). Higher CAR was an independent prognostic factor of overall survival.
|
| Vujic [23] |
A total of 202 patients with resected PDAC were included. A cut-off value of 0.0003 for CAR was determined. CAR was an independent prognostic factor of overall survival in univariate and multivariate Cox regression analysis. Elevated CAR was associated with a higher median value of the Charlson Index, a higher Union for International Cancer Control) classification and increased carcinoembryonic antigen levels.
|
| Ikuta [24] |
A total of 136 patients with resected PDAC were included. A cut-off value of 0.09 for CAR was determined. High CAR was an independent predictor of poor overall survival (p = 0.03).
|
| Ikeguchi [25] |
A total of 43 patients with resected PDAC were included. A cut-off value of 0.04 for CAR was determined. High CAR was strong preoperative marker of poor prognosis independently of tumor stage.
|
| Wu [26] |
A total of 233 patients with PDAC were included with an unspecified proportion of resectable disease. A cut-off value of pre-treatment (surgical or chemotherapy) 0.54 for CAR was determined. CAR was identified as the only inflammation-based parameter with an independent prognostic ability in the multivariate analyses (p < 0.001).
|
| Haruki [27] |
A total of 113 patients with resected PDAC were included. A cut-off value of 0.03 for CAR was determined. Higher CAR (p = 0.023) was an independent and significant predictor of poor patient outcome.
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